Cognitive Neuropsychology & Physiopathology of Schizophrenia - Team "Psychiatry"
Anne Giersch
email: giersch[at]unistra.fr
The team aims to understand the pathophysiology of mental diseases, in order to develop new therapies. The team addresses these questions by focusing on a few cognitive disorders, i.e. autobiographical memory, attention and perception disorders, as well as emotional regulation, while aiming to relate them with clinical symptoms, and especially the disorders of the sense of self. Those questions are applied to schizophrenia, depression, post-traumatic disorders, ADHD and borderline personality.
Research areas: Autobiographical memory ; Attention & perception disorders ; Emotional regulation.
Techniques: Experimental psychology ; Electroencephalography ; Motion capture ; Eyetracking ; Whole-body motion platform ; Virtual reality.
Cognitive Neuropsychology & Physiopathology of Schizophrenia - Team "Addiction"
Laurence Lalanne & Emmanuel Darcq
email: llalanne[at]unistra.fr & edarcq[at]unistra.fr
The Addictions team, is based at the CRBS (Centre de Recherche Biomédicale de Strasbourg) in the INSERM STEP Unit, and studies the mechanisms of addictive disorders to opioids, alcohol and cannabis in relation to psychiatric comorbidities. The team is translational, with clinical research led by Laurence Lalanne and pre-clinical research led by Emmanuel Darcq. The clinical research team, focuses on the problem of addictive disorders in relation to psycho-social and epigenetic factors. The pre-clinical team goals are to elucidate the neurobiological mechanisms, and more specifically the brain circuits involved in relapse and abstinence. Pre clinical team is also studying the role of G protein-coupled receptors (GPCRs) in addictive disorders.
Research areas: Addiction ; Depression ; Opioids ; Cocaine ; cannabis.
Techniques: Clinical techniques and Preclinical ; Behavioural tests ; Optogenetic ; Fiber photometry ; Spatial transcriptomic.
Cognitive Neuropsychology & Physiopathology of Schizophrenia - Team "SLA-DFT"
Caroline Rouaux
email : caroline.rouaux[at]inserm.fr
Our lab is dedicated to understanding amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two neurodegenerative disorders that translate into either motor (ALS) or behavioral and cognitive impairments (FTD), and are linked by genetics, histopathology and in certain cases a convergence of clinical manifestations. Using animal and human iPSC-derived cellular models, as well as investigation of patients through collaborations, we develop translational approaches to unravel circuit, cellular, molecular and genetic disease mechanisms, to identify new therapeutic targets and biomarkers, and develop and test novel therapeutic strategies.
Research areas: Neurodegeneration.
Techniques: Genetics ; Cellular biology ; Molecular biology ; Electrophysiology ; Behavior ; Neuromodulation.