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Abstract Translational research is essential to bridge the gap between basic neuroscience and clinical practice, particularly in psychiatry, where the complexity of brain function and the heterogeneity of disorders hinder therapeutic progress. Substance use disorders (SUDs) represent a compelling…
Abstract Until recently, it was widely assumed that oxytocin signaling occurred exclusively through the activation of neuronal oxytocin receptors, with neurons being the primary targets of released oxytocin. However, this view was challenged by the discovery of functional oxytocin receptors in…
Abstract Thermal and tactile sensations interact in shaping how we perceive our environment. These interactions rely on the activity of distinct but converging somatosensory pathways and may be altered by aging. In this study, we investigated how innocuous thermal stimulation modulates tactile…
Abstract The increasing prevalence of opioid use disorder (OUD) represents an important global public health crisis, often referred to as the ‘opioid epidemic’. Opioids are known for their potent pain-relieving effects, but also have serious side effects, including OUD and respiratory depression,…
Abstract Introduction: Opioid use disorder (OUD) is a chronic relapsing condition caused by prolonged opioid exposure, which triggers adaptive changes in the brain. These changes make it challenging to control or abstain from consuming, and significantly increase the risk of relapse. While the…
Modified nitazenes, opioids 1,000 times stronger than morphine, show remarkably few adverse effects in rodents, renewing the potential of these drugs for pain relief.
ABSTRACT Objective: The present study aimed to translate and validate the French version of the Pain Resilience Scale (PRS) that was initially created and validated within English‐speaking populations. Methods: A total of 137 participants experiencing chronic pain completed the French version of the…
La douleur neuropathique, conséquence d’une atteinte du système somatosensoriel, concerne jusqu’à 8 % de la population et demeure difficile à traiter. Une étude publiée dans The British Journal of Pharmacologymontre que la caractérisation pharmacologique des récepteurs opioïdes, même dans leur…
The “Opioid System, Nociception & Pain” team, led by Dominique Massotte, begins 2026 with three major publications in the field of pain neuroscience: “Divergence in Mu and Delta Opioid Receptor Pharmacology in Neurons and Antinociceptive Efficacy in Neuropathic Pain: Insights from MP135 and…
We are pleased to announce that Julia Devanne (PhD), clinical neuropsychologist and postdoctoral researcher with the Life Adversity and Pain team led by Pierrick Poisbeau at the Laboratory of Cognitive and Adaptive Neuroscience (LNCA, CNRS UMR 7364) in Strasbourg, has just published a major article…
The February–March–April 2026 issue of Le Figaro Santé features a special report on pain. Pierrick Poisbeau, a team leader at EURIDOL - Graduate School of Pain, contributes to the section entitled “Being Yourself” on chronic pain, alongside other specialists.This feature highlights a striking…
The special edition of Médecine de Science & Vie (March 2026) features an exceptional report on pain: biological mechanisms, therapeutic innovations and clinical perspectives. Entitled “Overcoming pain – New avenues for scientists”, this issue highlights major advances in the field. This special…
Edited by Pierrick POISBEAU and Meggane MELCHIOR. Physiological and pathological mechanisms of pain and analgesia.
EURIDOL is pleased to announce the publication in the journal eLife of the article entitled “Affinity-guided labeling reveals P2X7 nanoscale membrane redistribution during BV2 microglial activation”, now available in its final version (version of record). This work was carried out by the Ion Channel…
"Objectives Clinical studies revealed that early-life adverse events contribute to the development of IBS in adulthood. The aim of our study was to investigate the relationship between prenatal stress (PS), gut microbiota and visceral hypersensitivity with a focus on bacterial lipopeptides…
"The dorsal horn (DH) of the spinal cord is an important structure involved in the integration of nociceptive messages. Plastic changes in the properties of neuronal networks in the DH underlie the development of analgesia as well as of hyperalgesia and allodynia in acute and chronic pain states.…
"The voltage-gated sodium channel Nav1.7 is encoded by SCN9A gene and plays a critical role in pain sensitivity. Several SCN9A gain-of-function (GOF) mutations have been found in patients with small fiber neuropathy (SFN) having chronic pain, including the R185H mutation. However, for most of these…
"Chronic pain is a very disabling disease, which statistically affects women more than men. More and more studies are looking at this sexual difference. In particular, the study by Luo et al., published on September 1, 2021, highlights a particular neuroimmune axis that induces mechanical pain…
"Morphine remains the gold standard painkiller available to date to relieve severe pain. Morphine metabolism leads to the production of two predominant metabolites, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G). This metabolism involves uridine 5′-diphospho-glucuronosyltransferases…