Publications

2026

• Lalanne, L., Darcq, E., Kieffer, B.L. et al. The need for translational research to advance the understanding of substance use disorders. J Transl Med (2026). https://doi.org/10.1186/s12967-026-08909-1
• C. Denis, S. Stojilkovic, K.-Y. Wang, et al. “A Brain-Wide Atlas of Astrocytic Oxytocin Receptors Reveals a Glial Basis for Nucleus Accumbens Modulation of Affiliative Behavior.” Advanced Science (2026): e18450. https://doi-org.scd-rproxy.u-strasbg.fr/10.1002/advs.202518450
• Ljubica Jovanovic, Laurence Lalanne, Florent Bernardin, Vincent Laprévote, Anne Giersch, Passage of Time or Delay Signal at the Level of Milliseconds: A New Approach and a Selective Difficulty in Individuals With Schizophrenia, Schizophrenia Bulletin, Volume 52, Issue 3, May 2026, sbag064, https://doi.org/10.1093/schbul/sbag064
• Inquimbert P., Fitterer C., Hugel S., Jesic M., Goumon Y., Andry V., Schneider S., Daubeuf F., Faouzi A., Doridot S., Majumdar S., Bihel F., Schmitt M.,Massotte D. (2026) “Divergence in Mu and Delta Opioid Receptor Pharmacology in Neurons and Antinociceptive Efficacy in Neuropathic Pain: Insights from MP135 and CYM51010.” Brit J Pharmacol (in press) DOI: 10.1111/bph.70285
• Kaeffer J., Straub M.-L., Le Coz G.-M., Quillet R., Kugler V., Petit-Demoulière N., Gerum M., Zeder-Lutz G., Doridot S., Dumas M., Chicher J., Hammann P., Marin P., Vandermoere F., Massotte D., Simonin F. and Lecat S. (2026) “GPRASP1 deletion suppresses antinociceptive tolerance during chronic activation of delta opioid receptor in persistent pain.” Biomedicine & Pharmacotherapy 194, 11913.DOI: 10.1016/j.biopha.2025.118913
• Gaborit M., Leboulleux Q., Willem N., Sagot C., Doridot S., Herbeaux K., Kremer M., Bery A., Befort K. and Massotte D. (2026) “Chronic constriction of the sciatic nerve does not induce mood-related comorbidities in female mice.” Brain Behavior & immunity 134, 106086.
• Mamino E, Lithfous S, Pebayle T, Dufour A, Després O. Thermal modulation of tactile perception in young and older adults: Local and remote effects. Perception. 2026 Mar 10:3010066261426795. doi: 10.1177/03010066261426795. Epub ahead of print. PMID: 41804546.
• Super-potent opioids could be safer-than-expected alternatives to conventional painkillers. Mathis V, Darcq E.Nature. 2026 Apr 1. doi: 10.1038/d41586-026-00806-3. Online ahead of print.PMID: 41922748

2025

• Gkiouzeli, A., C. Tarquinio, E. Eby, et al. 2025. “ Translation and Validation of the Pain Resilience Scale in a French Population Suffering From Chronic Pain.” Journal of Clinical Psychology 82: 495–504. https://doi-org.scd-rproxy.u-strasbg.fr/10.1002/jclp.70080.
• The neural circuits and signalling pathways of opioid use disorder. Mathis VP, Ehrlich AT, Darcq E.Nat Rev Neurosci. 2025 Dec;26(12):778-797. doi: 10.1038/s41583-025-00982-7. Epub 2025 Oct 27.PMID: 41145836
• Incubation of social deficit during morphine abstinence in male mice using a novel unbiased and automatized method. Mathis VP, Giua G, Torquet N, Mittelhaeuser C, Bour R, Kieffer BL, Riet F, Darcq E.Front Behav Neurosci. 2025 Oct 29;19:1697469. doi: 10.3389/fnbeh.2025.1697469. eCollection 2025.PMID: 41234535

2023 

• Gaborit, M., & Massotte, D. (2023). Therapeutic potential of opioid receptor heteromers in chronic pain and associated comorbidities. British Journal of Pharmacology, 180(7), 994–1013. https://doi.org/10.1111/bph.15772
• Gabel, Florian et al. “Central metabolism as a potential origin of sex differences in morphine antinociception but not induction of antinociceptive tolerance in mice.” British journal of pharmacology vol. 180,7 (2023): 843-861. doi:10.1111/bph.15792
• Petitfils, Camille et al. “Identification of bacterial lipopeptides as key players in IBS.” Gut vol. 72,5 (2023): 939-950. doi:10.1136/gutjnl-2022-328084

2022

• Melchior, Meggane et al. “The burden of early life stress on the nociceptive system development and pain responses.” The European journal of neuroscience vol. 55,9-10 (2022): 2216-2241. doi:10.1111/ejn.15153
• Bohren, Y., Timbolschi, D. I., Muller, A., Barrot, M., Yalcin, I., & Salvat, E. (2022). Platelet-rich plasma and cytokines in neuropathic pain: A narrative review and a clinical perspective. European Journal of Pain, 26, 43–60. https://doi.org/10.1002/ejp.1846
• Gerum, Manon, et Frédéric Simonin. « Behavioral characterization, potential clinical relevance and mechanisms of latent pain sensitization ». Pharmacology & Therapeutics, vol. 233, 2022, p. 108032, https://doi.org/10.1016/j.pharmthera.2021.108032.
• Peverini, Laurie, et al. « Photo-isomerizable tweezers to probe ionotropic receptor mechanisms ». Current Opinion in Pharmacology, vol. 62, 2022, p. 109‑16, https://doi.org/10.1016/j.coph.2021.11.011.
• Lithfous, Ségolène, et al. « Investigating cold Aδ fibers in the 0–40 °C temperature range: A quantitative sensory testing and evoked potentials study ». Clinical Neurophysiology, vol. 134, 2022, p. 81‑87, https://doi.org/10.1016/j.clinph.2021.11.076.
• Hany, Romain et al. “High-Throughput Screening for Extracellular Inhibitors of the FLT3 Receptor Tyrosine Kinase Reveals Chemically Diverse and Druggable Negative Allosteric Modulators.” ACS chemical biology vol. 17,3 (2022): 709-722. doi:10.1021/acschembio.2c00048
• Megat, Salim, et al. « Antiallodynic action of phosphodiesterase inhibitors in a mouse model of peripheral nerve injury ». Neuropharmacology, vol. 205, 2022, p. 108909, https://doi.org/10.1016/j.neuropharm.2021.108909.
• Cathenaut, Lou; Leonardon, Benjamin; Kuster, Robin; Inquimbert, Perrine; Schlichter, Rémy; Hugel, Sylvain*. Inhibitory interneurons with differential plasticities at their connections tune excitatory–inhibitory balance in the spinal nociceptive system. PAIN 163(5):p e675-e688, May 2022. | DOI: 10.1097/j.pain.0000000000002460
• Gerum, Manon, et Frédéric Simonin. « Behavioral characterization, potential clinical relevance and mechanisms of latent pain sensitization ». Pharmacology & Therapeutics, vol. 233, 2022, p. 108032, https://doi.org/10.1016/j.pharmthera.2021.108032.
• Meggane Melchior, Mikhail Dziadzko, Séverine Conradi, Pierrick Poisbeau, and Frédéric Aubrun Impact of COVID-19 on chronic pain structures: data from French national survey. (2022) Journal of Comparative Effectiveness Research. DOI: 10.2217/cer-2022-0003
• Gabel F, Hovhannisyan V, Berkati A-K and Goumon Y (2022) Morphine-3-Glucuronide, Physiology and Behavior. Front. Mol. Neurosci. 15:882443. doi: 10.3389/fnmol.2022.882443
• Xue Y, Kremer M, Muniz Moreno MM, Chidiac C, Lorentz R, Birling M-C, Barrot M, Herault Y and Gaveriaux-Ruff C (2022) The Human SCN9AR185H Point Mutation Induces Pain Hypersensitivity and Spontaneous Pain in Mice. Front. Mol. Neurosci. 15:913990. doi: 10.3389/fnmol.2022.913990
• Leonardon B, Cathenaut L, Vial-Markiewicz L, Hugel S, Schlichter R and Inquimbert P (2022) Modulation of GABAergic Synaptic Transmission by NMDA Receptors in the Dorsal Horn of the Spinal Cord. Front. Mol. Neurosci. 15:903087. doi: 10.3389/fnmol.2022.903087

2021 

• Awad, Gaëlle, et al. « Artificial Sweeteners in Animal Models of Binge Eating ». Animal Models of Eating Disorders, édité par Nicole M. Avena, Springer US, 2021, p. 115‑31, https://doi.org/10.1007/978-1-0716-0924-8_7.
• Kaeffer, Juliette, et al. « GPRASP/ARMCX Protein Family: Potential Involvement in Health and Diseases Revealed by their Novel Interacting Partners ». Current Topics in Medicinal Chemistry, vol. 21, n^o 3, 2021, p. 227‑54, https://doi.org/10.2174/1568026620666201202102448.
• Kamoun, Nisrine, et al. « Long-lasting analgesic and neuroprotective action of the non-benzodiazepine anxiolytic etifoxine in a mouse model of neuropathic pain ». Neuropharmacology, vol. 182, 2021, p. 108407, https://doi.org/10.1016/j.neuropharm.2020.108407.
• Michel Barrot, Ipek Yalcin, « Depression in focus: Insights from animal and human data, from molecular to behavioural analyses ». European Journal of Neuroscience, vol. 53, Issue 1, 2021, p. 5-8, https://onlinelibrary.wiley.com/doi/10.1111/ejn.15101.
• Kremer, Mélanie et al. “How to study anxiety and depression in rodent models of chronic pain?.” The European journal of neuroscience vol. 53,1 (2021): 236-270. doi:10.1111/ejn.14686
• Gazzo, Géraldine, et al. « Overexpression of chloride importer NKCC1 contributes to the sensory-affective and sociability phenotype of rats following neonatal maternal separation ». Brain, Behavior, and Immunity, vol. 92, 2021, p. 193‑202, https://doi.org/10.1016/j.bbi.2020.12.010.
• Quillet, Raphaëlle, et al. « Identification of an N-acylated-DArg-Leu-NH2 Dipeptide as a Highly Selective Neuropeptide FF1 Receptor Antagonist That Potently Prevents Opioid-Induced Hyperalgesia ». Journal of Medicinal Chemistry, vol. 64, n^o 11, juin 2021, p. 7555‑64, https://doi.org/10.1021/acs.jmedchem.1c00256.
• Breton, David Le. « De la souffrance d’existence à celle du corps ». Douleurs : Évaluation - Diagnostic - Traitement, vol. 22, n^o 3, 2021, p. 140‑47, https://doi.org/10.1016/j.douler.2021.04.003.
• De Neve, Jolien, et al. « Comprehensive overview of biased pharmacology at the opioid receptors: biased ligands and bias factors ». RSC Med. Chem., vol. 12, n^o 6, 2021, p. 828‑70, https://doi.org/10.1039/D1MD00041A.
• Naiditch, Nicolas et al. “Persistent Spinal Pain Syndrome Type 2 (PSPS-T2), a Social Pain? Advocacy for a Social Gradient of Health Approach to Chronic Pain.” Journal of clinical medicine vol. 10,13 2817. 25 Jun. 2021, doi:10.3390/jcm10132817
• Dunning, K., Martz, A., Peralta, F. A., Cevoli, F., Boué-Grabot, E., Compan, V., Gautherat, F., Wolf, P., Chataigneau, T., & Grutter, T. (2021). P2X7 Receptors and TMEM16 Channels Are Functionally Coupled with Implications for Macropore Formation and Current Facilitation. International Journal of Molecular Sciences, 22(12), 6542. https://doi.org/10.3390/ijms22126542
• Joshi, Anil, et al. « Midbrain and Lateral Nucleus Accumbens Dopamine Depletion Affects Free-choice High-fat high-sugar Diet Preference in Male Rats ». Neuroscience, vol. 467, 2021, p. 171‑84, https://doi.org/10.1016/j.neuroscience.2021.05.022.
• Dhanasobhon, Dhanasak, et al. « Enhanced analgesic cholinergic tone in the spinal cord in a mouse model of neuropathic pain ». Neurobiology of Disease, vol. 155, 2021, p. 105363, https://doi.org/10.1016/j.nbd.2021.105363.
• Gazzo G, Salgado Ferrer M, Poisbeau P (2021) The non-benzodiazepine anxiolytic etifoxine limits mechanical allodynia and anxiety-like symptoms in a mouse model of streptozotocin-induced diabetic neuropathy. PLOS ONE 16(8): e0248092. https://doi.org/10.1371/journal.pone.0248092
• Nogueira, David de Sa, et al. « Binge sucrose-induced neuroadaptations: A focus on the endocannabinoid system ». Appetite, vol. 164, 2021, p. 105258, https://doi.org/10.1016/j.appet.2021.105258.
• Marchal, A., Melchior, M., Dufour, A., Poisbeau, P., Zores, C., & Kuhn, P. (2021). Pain Behavioural Response to Acoustic and Light Environmental Changes in Very Preterm Infants. Children, 8(12), 1081. https://doi.org/10.3390/children8121081
• Letellier, Baptistea,b; Kremer, Mélaniea; Becker, Léa J.a; Andry, Virginiea; Goumon, Yannicka; Leboulleux, Quentina; Hener, Pierrea; Inquimbert, Perrinea; Couqueberg, Nolwenna; Waltisperger, Elisabetha; Yalcin, Ipeka; Mouthon, Franckb; Droguerre, Marineb; Charvériat, Mathieub; Barrot, Michela,*. Action of mefloquine/amitriptyline THN101 combination on neuropathic mechanical hypersensitivity in mice. PAIN 162(12):p 2841-2853, December 2021. | DOI: 10.1097/j.pain.0000000000002276
• Gieré, Clémencea; Melchior, Megganea; Dufour, Andréb; Poisbeau, Pierricka,*. Spinal integration of hot and cold nociceptive stimuli by wide-dynamic-range neurons in anesthetized adult rats. PAIN Reports 6(4):p e983, November/December 2021. | DOI: 10.1097/PR9.0000000000000983 

2020 

• Dufour, André et al. “Thermal sensitivity in humans at the depth of thermal receptor endings beneath the skin: validation of a heat transfer model of the skin using high-temporal resolution stimuli.” European Journal of Applied Physiology 120 (2020): 1509 - 1518.
• Zhou S, Lithfous S, Després O, Pebayle T, Bi X and Dufour A (2020) Involvement of Frontal Functions in Pain Tolerance in Aging: Evidence From Neuropsychological Assessments and Gamma-Band Oscillations. Front. Aging Neurosci. 12:131. doi: 10.3389/fnagi.2020.00131
• Faivre, Fanny et al. “Ablation of the tail of the ventral tegmental area compensates symptoms in an experimental model of Parkinson's disease.” Neurobiology of disease vol. 139 (2020): 104818. doi:10.1016/j.nbd.2020.104818
• Humo, Muris et al. “Ketamine induces rapid and sustained antidepressant-like effects in chronic pain induced depression: Role of MAPK signaling pathway.” Progress in neuro-psychopharmacology & biological psychiatry vol. 100 (2020): 109898. doi:10.1016/j.pnpbp.2020.109898
• Becker, Léa J., et al. « Comorbidity of chronic pain and anxiodepressive disorders: Deciphering underlying brain circuits ». Neuroscience & Biobehavioral Reviews, vol. 115, 2020, p. 131‑33,
• Gabel, Florian, et al. « Central metabolism as a potential origin of sex differences in morphine analgesia but not in the induction of analgesic tolerance in mice ». bioRxiv, janvier 2020, p. 2020.12.07.414185, https://doi.org/10.1101/2020.12.07.414185.
• Segolene Lithfous, Olivier Després, Thierry Pebayle, Claudia Casadio, Andre Dufour, Accurate Determination of the Cold Detection Threshold with High-Speed Cooling of the Skin, Pain Medicine, Volume 21, Issue 12, December 2020, Pages 3428–3436, https://doi.org/10.1093/pm/pnaa246