Ardem Patapoutian, professeur au Scripps Research Institute en Californie, est Prix Nobel de physiologie ou médecine 2021 pour la découverte des récepteurs impliqués dans la mécanosensation, à l’origine du toucher et de la proprioception. Nous avons eu l’immense joie de l’accueillir pour 3 jours sur Strasbourg dans le cadre du programme « CNRS fellows-ambassadeurs ». Lors de cette visite, des échanges riches ont eu lieu avec les étudiants, doctorants de l’Ecole Universitaire de Recherche Euridol et de l’lnstitut Thématique (ITI) NeuroStra, ainsi qu’avec les équipes et chercheurs locaux en neurosciences et les représentants du CNRS et de l’Université de Strasbourg. Au-delà de ces rencontres scientifiques, des moments de convivialité ont aussi permis de lui faire découvrir Strasbourg et l’Alsace. Le lundi 26 mai, plus de 160 personnes ont pu assister à sa conférence "May the Force be with you! Piezo channels in mechanosensory biology", distinguished lecture USIAS (University of Strasbourg Institute for Advanced Science).

Un grand merci au professeur Patapoutian pour ces journées partagées avec notre communauté scientifique ! 

12 laboratoires - 32 équipes - 10 plateformes - 8 services hospitaliers

Découvrir le Neuropôle

Effectiveness of an audiovisual telerehabilitation program on visual field restoration in children with hemianopia consecutive to a brain tumour.

Thesis funded for 3 years under a European grant (European Science Foundation).

Procedures

Interventional data analysis from the virtual reality headset (safety, performance, adherence/compliance, eye/head tracking)

Primary outcome data analysis (visuel fields)

Secondary and exploratory outomes measures and data analysis (VEP, SD-OCT, questionnaires)

Collaborative work involving 2 clinical departemnt at HUS (opthalmology and pediatrci neuro-oncology)

International collaboration with European consortium (8 clinical sites in 7 countries: Strasbourg, Milan, Padova, Barcelona, Vienna, Utrecht, London, Copenhagen).

Pre-requisite

Master in Neurosciences or equivalent (MSc, MD). Comprehensive knowledge of the visual system.

Minimum B2 level in English. Knowledge of another european language is a plus. Comprehensive knowledge of Python (coding), biomedical statistics/epidemiology. Strong interest for innovating technologies. Knowledge of clinical trials regulations.

Contact

Michael REBER lab, Strasbourg Translational Neuroscience & Psychiatry UMR-S1329

michael.reber[at]inserm.fr

Assaf Breska, Independent group leader, Max-Planck institute for Biological Cybernetics, Tübingen

Invited by: Anne Giersch & Philippe Isope

To survive in a rapidly dynamic world, the brain predicts the “what”, “where” and “when” of upcoming events and proactively adjusts perception, attention and action. The cerebellum has traditionally been associated with prediction and timing in the motor domain, while proactive perception and attention were associated with oscillatory mechanisms in cortical circuits. I will present a series of studies that combined computational modelling, psychophysics, and EEG recording in healthy and neurological populations to investigate mechanisms of dynamic prediction and the potential role of the cerebellum beyond motor control. These reveal that the cerebellum is indeed involved in non-motor prediction, of the timing of sensory events, as well as of semantic content in language. This is then leveraged to uncover causal cerebellar control of temporal variability in cortical circuits, identify unique entrainment mechanisms to isochronous streams, and study the computational overlap between implicit and explicit timing. Altogether, these findings expand our understanding of subcortical-cortical interactions in supporting prediction, timing, and high-level cognition, and inspire translational applications.

Early non-motor signs as a window into Amyotrophic Lateral Sclerosis pathophysiology

• 9:35 AM: Karine MERIENNE, LNCA, ITI NeuroStra

Epigenetic dysregulation in Huntington's disease

• 10:10 AM: Pierre-Eric LUTZ, INCI, ITI NeuroStra

Sex differences in epigenetic mechanisms of chronic opioid action

• 11:05 AM: Angelina ANGELOVA, Institut Galien, Université Paris-Saclay

Multicomponent lipid nanoparticles for neuroprotection and development of brain-targeted nanomedicines

• 11:40 AM: Philippe ISOPE, INCI, ITI NeuroStra

Synaptic connectivity maps and temporal processing in the cerebellar cortex

Organisers

• Manon Boivin
• Marianne Lemée
• Jacqueline Ji
• Charlotte Schmuck

Translational Medicine and Neurogenetics department, IGBMC

We study the contribution of microglial cells and underlying mechanisms of neuronal and glial dyshomeostasis in neurodegenerative conditions including Alzheimer´s disease (AD) and the childhood dementia Niemann-Pick type C (NPC). We use translational approaches to identify molecular fingerprints of microglial dysfunction and identify novel cellular targets to target and monitor neuroinflammation across neurodegenerative disorders.

September 20th 2024 at 11am
Institut des Neurosciences Cellulaires et Integratives; Salle de Seminaire
8, allée Général Rouvillois
Strasbourg

Host
Frank W. Pfrieger, INCI

Supported by BayFrance

Our research aims to explore the intricate interactions between Müller cells, microglia and neurons in both healthy and diseased retinas. We are particularly interested in understanding the effects of AAV-vectored gene therapies targeting these interactions, in particular the coordination of the retinal immune response, for example by modulating retinal complement homeostasis or glucocorticoid receptor signaling. We demonstrate that our approach of delivering therapeutic gene expression to Müller cells can improve disease progression in models of diabetic retinopathy or ischemic stress, independent of the underlying cause of the disease, and thus may benefit patients who are not candidates for currently available treatment strategies, since most, if not all, retinal diseases involve Müller cell gliosis and inflammatory processes that potentially accelerate neuronal dysfunction.

September 19th 2024 at 10:30am
Institut des Neurosciences Cellulaires et Integratives; Salle de Seminaire
8, allée Général Rouvillois á Strasbourg

Host
Frank W. Pfrieger, INCI

Supported by BayFrance

Two co-financings are proposed in 2025. The doctoral contract will start no earlier than January 1, 2025 and no later than October 1, 2025.
Deadline to apply: November 28th, 2024.

Download the application forms below.