INCI conference - From MCD to circadian rhythms: Importance of the intracellular transport
Amandine BERY obtained her PhD at the University of Barcelona thanks to the study of CNS1,2 in an Evo-Devo approach. Then she has completed three postdoctoral fellowships at Institut A. Fessard in Gif-sur-Yvette, CEA in Fontenay-aux-Roses and Institut Imagine/Hôpital Necker Enfants Malades8-11 in Paris. She was first interested in molecular mechanisms regulating the proliferation of progenitors during the development of the cerebral cortex, especially the dynamic of the cytoskeleton and related human pathologies, such as dyneinopathies and tubulinopathies.
During her three post-doctoral periods, her work allowed:
- identify the cis-regulatory logic related to the behavior and heterogenity of cortical progenitors, therefore underlining the importance to identify enhancers for a better understanding of the corticogenesis3,4.
- characterize the Xlf-deficient mouse as new model of the malformations of cerebral development (MCD) and identify XLF as a new candidate gene of autism spectrum disorder (ASD) 5-7.
- bring new data that help strive for greater understanding of MCD8-10, especially an advance comprehension of brain versus peripheral dyneinopathies with a new approach allowing a better classification of both MCD and SMA-LED phenotype11.
By joining the team "Light, vision and the brain" as teacher-researcher, she will first contribute to running projects thanks to her expertises in molecular and cellular processes, in electroporation of mouse embryonic cortex and cell transfection, in imaging and bioinformatics for genetic analyses. Further, she will develop her own project that aims to understand "How circadian rhythms modulate the intracellular transport in the signalling of growth, survival and death in the retinal cell?"
1. Bery A et al (2010). Structure of the central nervous system of a hatchling acoel, Symsagittifera roscoffensis. Dev Genes Evol 220(3):61-76
2. Bery A & Martinez P (2011). Acetylcholinesterase activity in the developing and regenerating nervous system of the acoel Symsagittifera roscoffensis. Acta Zool 92(4):383-92
3. Bery A et al (2013). Identification and characterization of enhancers active in mouse embryonic cerebral cortex highlights the heterogeneity of cortical progenitors. Cereb Cortex 24(11):2822-34
4. Bery A et al (2016). Genes expressed in mouse cortical progenitors are enriched in Pax, Lhx, and Sox transcription factor putative binding sites. Brain Res 1633: 37-51
5. Etienne O, Bery A* et al (2014). Assessing cell cycle progression of neural stem and progenitor cells in the mouse developing brain after genotoxic stress. J Vis Exp 87:e51209
6. Bery A, Etienne O, Laugeray A, Desmaze C, Gauthier LR, Martin M, Boumezbeur F, Peres E, de Villartay JP, Le Bihan D, Mortaud S, Menuet A, Boussin F (under revision). Genes & Development. Xlf Deficiency Impairs Brain Development and Cognitive Abilities in mice.
7. Bery A, Laugeray A, Autier-Dérian D (under revision). Laboratory Animals. Is my test assessing stress or anxiety-related behaviors? Practical handbook for rodents.
8. Vegas N, … Bery A* & Bahi-Buisson N* (2018). Delineating the phenotypic spectrum of FOXG1 syndrome: from congenital microcephaly to hyperkinetic encephalopathy. Neurol Genet in press
9. Cavallin M, … Bery A* & Bahi-Buisson N* (2018). TLE1, a key player in neurogenesis, a new candidate gene for autosomal recessive postnatal microcephaly. Eur J Med Genet. pii: S1769-7212(17)30773-5
10. Cavallin M, Bery A* et al (2018). Recurrent RTTN mutation leading to severe microcephaly, polymicrogyria and growth restriction. Eur J Med Genet pii:S1769-7912(17)30720-6
11. Bery A et al (in preparation). New insights of the genotype/phenotype correlation in DYNC1H1-related MCD and SMA-LED disorders: differential alteration of the dynein-dynactin complex
2018 La mesure génétique de l’intelligence est-elle pertinente ? The Conversation, Publié le 20 Juillet 2018 (https://theconversation.com/la-mesure-genetique-de-lintelligence-est-elle-pertinente-99092)
2018 Neurosciences : Comment pensent les anticonformistes. The Conversation, Publié le 25 Février 2018 (http://theconversation.com/neurosciences-comment-pensent-les-anticonformistes-89948)
Comité d'Animation et de Communication Scientifique de l'INCI
Marie-Pierre Laran-Chich, Etienne Challet, Sylvain Hugel & Stéphane Gasman