Leaders: Dr. Anne-Laurence BOUTILLIER et Pr. Jean-Christophe CASSEL
Research unit: Laboratory of Cognitive and Adaptative Neuroscience (LNCA) UMR 7364
The team's research focuses on the functional dynamics of memory consolidation and on the molecular and cellular mechanisms - particularly epigenetic mechanisms - responsible for memory deficits in neurodegenerative diseases (Alzheimer's disease and related disorders, Lewy body and fronto-temporal dementias, Huntington's disease). We are looking for epigenetic/transcriptomic signatures associated with the pathology (integrated analyses by high-throughput sequencing: RNA-seq, ChIP-seq, CUT & Tag-seq, ATAC-seq, 4C-seq...), in the different brain regions involved and in a cell-specific manner (neurons, astrocytes, micoglia, oligodendrocytes...). sorted by FACS/FANS or magnetic beads) from transgenic animal models (THY-Tau22, Thy1-SNCA, FUS∆NLS, HD R6/1, HD KI-Q140,...). We are studying how these signatures are modified by learning, and/or certain genetic (e.g. EpoE3/4) or environmental (e.g. radio frequency) risk factors, as well as by environmental enrichment (social, physical, novelty). The neurodegenerative diseases we study are currently incurable and many clinical tests have recently failed. Our research in neuro-epigenetics deciphers fundamental mechanisms associated with the diseases and could provide new therapeutic leads. The studies conducted in our team include characterisation from the molecular to the behavioural scale.