Dean BUONOMANO, professor of psychology and neurobiology at the University of California, Los Angeles (UCLA)

The ability to tell time, represent and encode temporal information, and use past experiences to predict the future, are among the most fundamental computations the brain performs. But how do networks of neurons tell time and encode temporal information in a flexible manner? Precisely because of the importance of time, we argue that most neural circuits are capable of temporal computations. But in contrast to the clocks on our wrists that rely on the same mechanism to tell time across a wide range of scales, the brain engages many different mechanisms and circuits to tell time. We and others have proposed that on the scale of seconds timing relies on neural population clocks: time-varying patterns of neural activity that emerge from the dynamics of recurrent neural circuits. More generally, we propose that such dynamic regimes represent a fundamental computational strategy in the brain.

Entrée gratuite, mais inscription obligatoire sur https://www.eventbrite.com/e/billets-visites-du-centre-de-recherche-en-biomedecine-de-strasbourg-853544423347?aff=oddtdtcreator

PROGRAMMATION

10h : Ouverture des portes

Conférences grand public

Durée : 20 min de présentation, 10 min pour répondre à vos questions – À partir de 7 ans

• 10h30 : « Trouble de l’usage d’opiacés et marqueurs biopsychosociaux : à propos de deux projets », Pr. Laurence LALANNE
• 11h30 : « Actualités sur le Sclérose Latérale Amyotrophique ou Maladie de Charcot », Dr. Marie-Céline FLEURY
• 14h30 : « Le cerveau, un organe aux frontières bien gardées : exemple de la barrière hémato-encéphalique », Dr. Guillaume BECKER

Visites de nos locaux

Durée : 30min par visite – À partir de 7 ans

• Visite guidée de la plateforme d’imagerie
• Visite guidée d’un laboratoire de recherche

Ateliers ludiques autour de la science

Durée : 5-10min par atelier – À partir de 7 ans

• Hypothèse anatomo-fonctionnelle : découvrez comment est organisé le cerveau et comment chaque région se spécialise dans une fonction
• Les neurones communiquent : apprenez comment l’information est transmise dans les différentes zones du cerveau, et participez à un jeu où votre rapidité sera mise à l’épreuve !
• Colore ton neurone : à travers la coloration d’une lame, découvrez comment marquer et observer les neurones
• Développement cérébral : observez l’évolution du cerveau entre différentes espèces animales
• Défie ton cerveau ! Défiez votre cerveau avec des jeux de mémoire ou logique et des illusions d’optique !

Stands associatifs

• Association pour la Recherche sur la Sclérose Latérale Amyotrophique (ARSLA)
• Épilepsie France (10h-10h30 uniquement)
• Association Huntington France (AHF)

2024 has well started and it is time to present you what are the amazing ongoing  projects at Doctoneuro's board

Téléthon charity night Feedbacks – 19.12.2023

The last tuesday before Xmas holidays, we organized a charity concert at the K'fet des Sciences, with music played by the Mygales Détendues and collected money was given to Téléthon.

Thanks to you and your amazing energy, it was a huge success and we collected 400€ that were distributed to Téléthon.

Doctoneuro's sweaters are on their way !

We do not forget you, the warmy 2023-2024 doctoneuro sweater that you ordered are on their way to join your labs and classrooms.

 Stay tuned to be able to recover it as soon as we'll receive it !

NeuroThem events

New this year, NeuroTechs are replaced by Neurothems. The aim is to talk about neuroscience thematics, in an unofficial and chill atmosphere at the K'fet des Sciences, all of this followed by memorable parties.

You voted for the subjects of the year which will be 2 of these 3: Social Interactions / Lifestyle Influence / Other models

 Doctoneuro Week-End & parties, we need your ideas !

Our cohesion department is working hard to prepare your next festive event !

If you are interested in giving a hand to organize the festive parts of NeuroThems nights, or to think about the fun and original activities that we could set up during Doctoneuro's weekend, do not hesitate to contact us !

Oh !... About that.... you should maybe book your April 6-7th week-end

Plenty of other projects are on the starting block !

Stay tuned and do not hesitate to join our board meetings if you are curious to know more and be implicated in their succesfull onset

Thanks a lot for reading us, see you next month!

12 laboratoires - 32 équipes - 10 plateformes - 8 services hospitaliers

Découvrir le Neuropôle

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease of the adult motor system, for which effective treatments remain elusive. Mutations leading to the mislocalization of FUS, an essential RNA-binding protein, have been linked to the most severe form of ALS. Despite intense research efforts, the cascade of pathological events triggering the progressive degeneration of motor neurons remains incompletely understood. Our prior investigations revealed significant lipid metabolism alterations in the spinal cord of a FUS mouse model, as well as in motor neurons derived from ALS patients induced pluripotent stem cells (iPSCs). Recent evidence suggests that dysfunctional glial cells, including oligodendrocytes, contribute to neurodegeneration in FUS-linked ALS through non-cell autonomous mechanisms. In our latest research, we investigated the impact of FUS mutations in oligodendrocyte progenitor cells (OPCs) derived from human iPSCs. Confirming the cytoplasmic mislocalization of FUS in OPCs, we uncovered significant alterations in lipid metabolism, accompanied by transcriptomic alterations related to myelin formation. Additionally, we observed mitochondria-associated ER membrane abnormalities, ER stress, and mitochondrial dysfunctions. These recent findings emphasize the pathological role of FUS in oligodendrocytes, shedding light on the intricate cellular mechanisms contributing to FUS-linked ALS pathology.

Un contrat IE de 2 ans (débutant janvier 2024) est ouvert à l’INCI UPR3212 pour mener un projet de neuroanatomie humaine (histologie, immunohistochimie, RNAscope).
Pour candidater et pour plus d’information, merci de contacter : Michel Barrot (mbarrot@inci-cnrs.unistra.fr) à l’INCI.

A full audience round table is planned, followed by a coffee break where you will be able to meet the speakers individually.

Find more informations on NeuroStra website ! 

Join us and come to vote for the next board, everyone is welcome !

• If you are curious to see the activity/moral report
• If you love money and want to know more about the financial report
• If you have any propositions/suggestions for the coming year
• If you want to be part of the next board

Bio: Philipp Sterzer is a psychiatrist, neurologist and neuroscientist who trained in Frankfurt am Main, London and Berlin and held a professorship for psychiatry and computational neuroscience at Charité Berlin from 2011 to 2022. Recently, he was appointed Professor of Translational Psychiatry at University of Basel, Switzerland. His work focuses on the investigation of predictive neural processes in perception and their alterations in psychotic disorders using functional neuroimaging and computational modeling among other methods. Along with numerous articles in scientific journals and textbooks, he recently published “Die Illusion der Vernunft”, a popular science book on delusions and other irrational beliefs.