Invited by Nicolas Vitale (vitalen@unistra.fr )
The Scheiffele group uses an in vivo cell biology approach to uncover mechanisms of neuronal network formation in health and disease. They are seeking to understand molecular mechanisms of synapses formation, developmental remodeling, and plasticity. They apply a broad range of molecular, anatomical, imaging, electrophysiological, and behavioral assessments in rodents. A particular focus is on mRNA alternative splicing and translation, and its dysregulation in autism spectrum disorders. Based on the insights in developmental studies, the Scheiffele lab is developing therapeutic strategies using small molecules and splicing therapeutics for genetically-defined neurodevelopmental conditions.
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Comité d'Animation et de Communication Scientifique de l'INCI
Amandine Bery, Caroline George, Jennifer Kaufling, Marie-Pierre Laran-Chich, Hervé Cadiou, Stéphane Gasman, Yannick Goumon & Antoine Valéra
