Laurent KOESSLER

CRAN, UMR 7039, CNRS - Université de Lorraine
CHRU Nancy - University Hospital of Nancy

Invited by Valérie Simonneaux and Jean-Christophe Cassel

Abstract

Until a couple of year ago, the contribution of electrical potentials from brain sources to scalp EEG remains unclear and debated among the neuroscience community. Scalp EEG recording is largely used both in medical diagnosis (especially in epilepsy) and in cognition in order to detect and localize brain sources thanks to its non-invasive way of recording, its low cost and its easy way to use. In Nancy, a new program of simultaneous multi-scale EEG investigation in human is developed. Until now, only 5 centers in worldwide are able to do such recordings in human. Several results will be presented in order to show that the scalp EEG contribution is not as simple and predictive as one might think and that new electrophysiological biomarkers can be find in scalp EEG signals. At last, some biophysical aspects will be presented like volume conduction modeling and electrical source localization using inverse problem methods.

Selected recent publications

1. The inferior occipital gyrus is a major cortical source of the face-evoked N170: Evidence from simultaneous scalp and intracerebral human recordings. Jacques C, Jonas J, Maillard L, Colnat-Coulbois S, Koessler L*, Rossion B*. Hum Brain Mapp. 2019 Apr 1;40(5):1403-1418.

2. The standardized EEG electrode array of the International Federation of Clinical Neurophysiology. Seeck M, Koessler L, Bast T, Leijten F, Michel C, Baumgartner C, He B, Beniczky S. Clin Neurophysiol. 2017 Oct;128(10):2070-2077.

3. In-vivo measurements of human brain tissue conductivity using focal electrical current injection through intracerebral multicontact electrodes. Koessler L, Colnat-Coulbois S, Cecchin T, Hofmanis J, Dmochowski JP, Norcia AM, Maillard LG. Hum Brain Mapp. 2017 Feb;38(2):974-986.

4. Correlation of invasive EEG and scalp EEG. Ramantani G, Maillard L, Koessler L. Seizure. 2016 Oct;41:196-200.

5. Catching the invisible: mesial temporal source contribution to simultaneous EEG and SEEG recordings. Koessler L, Cecchin T, Colnat-Coulbois S, Vignal JP, Jonas J, Vespignani H, Ramantani G, Maillard LG. Brain Topogr. 2015 Jan;28(1):5-20.

6. Simultaneous subdural and scalp EEG correlates of frontal lobe epileptic sources. Ramantani G, Dümpelmann M, Koessler L, Brandt A, Cosandier-Rimélé D, Zentner J, Schulze-Bonhage A, Maillard LG. Epilepsia. 2014 Feb;55(2):278-88. doi: 10.1111/epi.12512. Epub 2014 Jan 13.

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The INCI conferences are organized by the Comité d'Animation et de Communication  Scientifique de l'INCI
Marie-Pierre Laran-Chich, Etienne Challet, Sylvain Hugel & Stéphane Gasman